Search results for "Chimeric proteins"

showing 3 items of 3 documents

Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.

2020

Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia (AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most curable form of AML. The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review of these translocations, discussing 15 different variants. Reviewed genes involved in APL variants include: ZBTB16, NPM, NuMA, STAT5b, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMDTS17, STAT3, and TFG. The genotypic and phenotypic …

Acute promyelocytic leukemiaGenotypeSTAT5BChromosomal translocationFusion geneslcsh:RC254-282Translocation GeneticFusion gene03 medical and health sciences0302 clinical medicineLeukemia Promyelocytic AcuteAcute promyelocytic leukemiaimmune system diseasesMedicineHumansneoplasmsPRKAR1AGeneRARAlcsh:RC633-647.5business.industryMyeloid leukemialcsh:Diseases of the blood and blood-forming organsHematologyGeneral Medicinelcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseFusion proteinNeoplasm ProteinsOncology030220 oncology & carcinogenesisCancer researchbusinessChimeric proteins030215 immunologyHematology/oncology and stem cell therapy
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Proteinaceous and oligosaccharidic elicitors induce different calcium signatures in the nucleus of tobacco cells.

2005

We previously reported elevated cytosolic calcium levels in tobacco cells in response to elicitors [D. Lecourieux, C. Mazars, N. Pauly, R. Ranjeva, A. Pugin, Analysis and effects of cytosolic free calcium elevations in response to elicitors in Nicotiana plumbaginifolia cells, Plant Cell 14 (2002) 2627-2641]. These data suggested that in response to elicitors, Ca2+, as a second messenger, was involved in both systemic acquired resistance (RSA) and/or hypersensitive response (HR) depending on calcium signature. Here, we used transformed tobacco cells with apoaequorin expressed in the nucleus to monitor changes in free nuclear calcium concentrations ([Ca2+](nuc)) in response to elicitors. Two …

Hypersensitive responsePhysiologyAequorinMutant Chimeric Proteinschemistry.chemical_elementOligosaccharidesCalciumTobaccoCalcium SignalingPhosphorylationMolecular BiologyCells CulturedCalcium signalingPlant ProteinsCell Nucleusbiologyfood and beveragesCell BiologyElicitorCytosolchemistryBiochemistrySecond messenger systemGene Targetingbiology.proteinSystemic acquired resistanceCell calcium
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Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus.

2009

Hippocampal theta rhythm is thought to underlie learning and memory, and it is well established that “pacemaker” neurons in medial septum (MS) modulate theta activity. Recent studies in the rat demonstrated that brainstem-generated theta rhythm occurs through a multisynaptic pathway via the nucleus incertus (NI), which is the primary source of the neuropeptide relaxin-3 (RLN3). Therefore, this study examined the possible contribution of RLN3 to MS activity, and associated hippocampal theta activity and spatial memory. In anesthetized and conscious rats, we identified the ability of intraseptal RLN3 signaling to modulate neuronal activity in the MS and hippocampus and promote hippocampal the…

MaleStilbamidinesCognitive NeuroscienceMutant Chimeric ProteinsPresynaptic TerminalsHippocampusNeuropeptideBiotinNerve Tissue ProteinsHippocampal formationNeuropsychological TestsHippocampusRats Sprague-DawleyCellular and Molecular NeuroscienceMicroscopy Electron TransmissionMemoryPonsNeural PathwaysPremovement neuronal activityAnimalsInsulinTheta RhythmNeuronsAnalysis of VarianceBehavior AnimalRhodaminesSpectrum AnalysisRelaxinProteinsDextransSpontaneous alternationNucleus IncertusRatsNeuropsychology and Physiological Psychologynervous systemSpace PerceptionExploratory BehaviorCholinergicSeptum of BrainRelaxin-3PsychologyPeptidesNeuroscienceProto-Oncogene Proteins c-fosLearningmemory (Cold Spring Harbor, N.Y.)
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